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Surface Modification of Hemodialysis Membrane for Enhancement of Their Performance

Noori Gooshki, Mahdiyeh | 2016

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 48794 (06)
  4. University: Sharif University of Technology
  5. Department: Materials Science and Engineering
  6. Advisor(s): MoosavI, Abbas; Abdekhodaie, Mohammad Jafar
  7. Abstract:
  8. A new technique for surface modification of flat sheet hemodialysis membranes has been investigated. This new strategy presents a dynamic surface modification for membranes in order to assess the hydrophilicity, antifouling, and biocompatibility effects of two functional monomers on dialysis membrane. PSF membranes containing polyvinylpyrrolidone were prepared via phase inversion technique. Afterward, free radical polymerization combined with surface polymerization used to introduce acrylic acid and 2-hydroxyethyl methacrylate onto polysulfone membrane surface. Various monomer concentrations were selected to obtain an optimum condition. Field emission scanning electron microscope (FE-SEM), attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and atomic force microscopy (AFM) confirmed that monomers successfully were grafted onto the membrane surface. Biocompatibility of the membrane evaluated via activated partial thromboplastin time (APTT), prothrombin time (PT) and cytotoxicity experiments. Which confirmed the blood compatibility and cytocompatibility of the modified membranes. It is also worth noting that APTT enhanced 35% for the best blood compatible sample. Water contact angle (WCA) and pure water flux measurements represented incredibly enhancement of membrane hydrophilicity. WCA decreased from 71° to 45° which corresponds with negative charge of membrane surfaces. Also, protein antifouling property increased noticeably from 79% to 38%. Nevertheless, urea, creatinine and vitamin B12 clearance have slightly increased. By and large, both blood compatibility and performance properties of modified membrane enhanced incredibly
  9. Keywords:
  10. Hemodialysis ; Biocompatibility ; Surface Modification ; Polysulphone Membrane ; Radical Polymerization ; Hydroxyethyl Methacrylat

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