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Dendritic multi-walled carbon nanotube with thermoresponsive shells: A good carrier for anticancer drugs
Pourjavadi, A ; Sharif University of Technology
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- Type of Document: Article
- DOI: 10.1016/j.jiec.2016.01.013
- Publisher: Korean Society of Industrial Engineering Chemistry
- Abstract:
- In this research, multi-walled carbon nanotubes (MWCNTs) were modified by dendritic macromonomer. Herein, polyamidoamine with acrylamide end groups was incorporated on MWCNTs. Afterwards, poly(N-isopropylacrylamide), (PNIPAM), was grafted on polyamidoamine in a facile synthesis. Then, doxorubicin as anticancer drug was loaded on this nanocarrier. The drug release was studied at below and above the lower critical solution temperature of PNIPAM, (LCST 32 °C), 27 °C and 37 °C, respectively. At 37 °C (body temperature) the polymer shell dehydrated and the drug release increased. The profile of drug release was expressed by Higuchi's equation which indicated that the drug release mechanism was diffusion controlled
- Keywords:
- Doxorubicin ; Drug delivery ; Multi-walled carbon nanotube ; Poly(N-isopropylacrylamide) ; Polyamidoamine ; Acrylic monomers ; Amides ; Carbon nanotubes ; Drug delivery ; Drug products ; Hydrogels ; Nanotubes ; Yarn ; Diffusion controlled ; Doxorubicin ; Drug release mechanism ; Facile synthesis ; Lower critical solution temperature ; Poly (n isopropylacrylamide) ; Polyamidoamines ; Thermo-responsive ; Multiwalled carbon nanotubes (MWCN)
- Source: Journal of Industrial and Engineering Chemistry ; Volume 35 , 2016 , Pages 332-340 ; 1226086X (ISSN)
- URL: http://www.sciencedirect.com/science/article/pii/S1226086X16000186