Modification of Gd-DTPA Contrast Agent for Targeted Drug Delivery be Nano Delivery

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Shahmanesh, Ashkan | 2015

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 49435 (07)
University: Sharif University of Technology
Department: Materials Science and Engineering
Advisor(s): Hamid Reza, Maddah Hosseini; Amo Abedini, Ghasem
Abstract:
One of the most useful method in medical imaging is Magnetic Resonance Imaging. Gadolinium base contrast agents used to improve images contrast made by MRI. There are some problems with using these drugs, such as toxicity and lack of targeting. In this research, Silicon nanoparticles were produced by a new fashion of removing template method. Particle size was scanned by Dynamic light scattering (DLS), mesoporous structure was investigated by Brunauer-Emmett-Teller (BET), and amine functionalization was recognized by Fourier transform infrared (FTIR). Functionality was determined by evaluation of signal and relaxation of nanoparticles.T1 was defined by a 1.5 tesla power MRI device. The results show that decrease was happened in r1, but in comparison with the other researches, this method is better. In similar studies with other method the relaxivity value was 1.7 mM-1s-1 in the best one, but by this method the rexalivity value of SiO2/Dg-DTPA is 1.8mM-1s-1
Keywords:
Magnetic Resonance Imagin (MRI) ; Targeted Druy Delivery ; Silica ; Fourier Transform Infra Red (FT-IR)Spectroscopy

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