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The Effect of Heart Dynamic Motion on LDL Concentration in Coronary Arteries

Seyed Hossein, Saeed | 2017

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 49894 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Dehghan Firoozabadi, Bahar
  7. Abstract:
  8. Heart attack is considered as one of the most common reasons of morality all over the world. Coronary Atherosclerosis is known as the major causes of heart attack. The commence and proceed of this disease is related to cross of Low Density Lipoprotein. In this project, based on numerical simulation using ANSYS Fluent, hemodynamic variables and the rate of LDL particles penetration to porous wall of coronary artery is investgated. The geometry is the first bifurcation of Left Anterior Descending and is located on the supposed sphere that represents heart configuration. Sinsuidal variations of shere radii, simulates pulsating movement of heart. Heart diameter is supposed to remain constant all over the simulations. Blood is considered as a Newtonian and compressible flow with pulsatile flow rate and real physiological profile. On walls plasma filtration boundary conditions is applied in order to simulate the penetration of particles to one-layer artery wall. Variations in concentration of LDL on artery wall and its relation to oscialltion os shear stress on artery wall under different conditions are presented. Also the effects of pulsating inlet flow and dynamic movement of artery are explored. Results show that the minimum amound of shear stress and the maximum concentration of LDL occur right in the place of the bifurcation and Myocardial wall which show similar results with respect to clinical experiments
  9. Keywords:
  10. Computational Fluid Dynamics (CFD) ; Coronary Arteries ; Low Density Lipoprotein (LDL) ; Concentration ; Dynamic Geometry

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