Loading...

Optimization of Beam Angles and Beam Weight in Intensity Modulated Radiation Therapy

Moazzami Goudarzi, Hadis | 2017

705 Viewed
  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 50151 (01)
  4. University: Sharif University of Technology
  5. Department: Industrial Engineering
  6. Advisor(s): Rafiee, Majid
  7. Abstract:
  8. external radiation therapy is a methods of cancer treatment or improvement of cancer-related complications. various techniques have been developed for external beam radiation therapy. Among which, Intensity Modulated Radiation Therapy (IMRT), due to its ability to adjust the intensity of radiation beams, has a higher capacity to generate appropriate dose distribution based on tumor size and volume. Intensity Modulated Radiation Therapy is one of the most commonly used procedures of delivering radiation to cancerous tissues, with the aim of reaching the prescripted dose in the target volume while minimizing damage to nearby healthy organs. Two decisions are of fundamental importance: to select the beam angles and calculate the beam intensities. Beam Angle selection is an important problem. Due to the large amounts of computational time, beam angles are often selected manually based on human experience and intuition. In this research, optimization of the angle and weight of the beams is considered simultaneously. Among the various models studied in the problem literature, two mixed integer models have been studied in this research, one of which integrates mixed integer programming with a linear objective function, and the other involves an integer programming model with a quadratic objective function. Then, considering the uncertain nature of the parameters presented in both models, the problem was modeled in form of robust optimization and solved. The models presented in the deterministic and the uncertainty of the parameters are evaluated and compared with a real sample of Tonsillar cancer and quality of the result from them, and their implementation time. The evaluations carried out between the results of both of the proposed models, compared to the CERR program output, provide greater protection for organs at risk while maintaining the minimum damage to the tumor. Also, the results of the quadratic mixed integer model show that no harm to healthy organs is achieved and in this respect superior to the integer linear mixed integer model
  9. Keywords:
  10. Intensity Modulated Radiation Therapy (IMRT) ; Fluence Map Optimization ; Mixed Integer Programming ; Treatment Planning ; Beam Angle Optimization

 Digital Object List

 Bookmark

No TOC