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Developing a mathematical model for Ibuprofen's controlled release accounting for solubility and diffusion effects

Vafajoo, L ; Sharif University of Technology | 2009

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  1. Type of Document: Article
  2. DOI: 10.1016/S1570-7946(09)70123-3
  3. Publisher: 2009
  4. Abstract:
  5. In this research a mathematical model for controlled drug delivery of Ibuprofen has been developed which accounts for physical kinetics based upon variations of the drug concentration, size and release time for a spherical drug pill. Through this model, the drug release for three sizes of the active ingredient including; 213nm (representing existence of only diffusion limitations), 515nm (representing existence of only solubility limitations) and 367nm (representing both diffusion and solubility limitations) was calculated. Theoretical amounts of the drug after two hours of release are calculated to be 95.3, 99.5 and 95.5 percent, respectively. Comparison of theoretical and experimental data enables one to conclude that when considering nano scale particle sizes for the active ingredient both solubility and diffusion mechanisms control the rate of the drug delivery. In other words, for small active ingredient particles corresponding to small drug pill diameters, the diffusion mechanism and for the drugs with bigger diameters the solubility mechanism is the rate controlling for the release of the Ibuprofen drug. On the other hand, for drugs with middle size diameters (i.e.; those between these two limits) both these are drug release rate controlling steps. © 2009 Elsevier B.V. All rights reserved
  6. Keywords:
  7. Controlled release ; Diffusion ; Modelling ; Solubility
  8. Source: Computer Aided Chemical Engineering ; Volume 26 , 2009 , Pages 737-742 ; 15707946 (ISSN); 9780444534330 (ISBN)
  9. URL: https://www.sciencedirect.com/science/article/pii/S1570794609701233