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Preparation and biological evaluation of [67Ga]-labeled- superparamagnetic nanoparticles in normal rats

Jalilian, A. R ; Sharif University of Technology | 2009

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  1. Type of Document: Article
  2. DOI: 10.1524/ract.2009.1566
  3. Publisher: R. Oldenbourg Verlag GmbH , 2009
  4. Abstract:
  5. Gallium-67 labeled superparamagnetic iron oxide nanoparticles ([ 67Ga]-SPION were prepared and evaluated for their altered biodistribution in normal rats. Superparamagnetic iron oxide nanoparticles (SPION) with narrow size distribution were synthesized by a co-precipitation technique using ferrous salts at Fe3+/Fe2+ = 2 molar ratio followed by structure identification using XRD, TGA, DSC, VSM, HRSEM, TEM and FT-IR techniques (≈ 5 nm diameter). In order to trace SPION bio-distribution, the radiolabeled iron oxide nanoparticles were prepared using 67Ga with a high labeling efficiency (over 96%, RTLC method) and they also showed an excellent stability at room temperature for at least 4 d. The biodistribution of the radiolabeled SPION was checked in normal male rats up to 24 h compared to free Ga3+ cation biodistribution. The data strongly support the alteration of the tracer accumulation in reticuluendothelial system while the stability of the complex is highly retained. © by Oldenbourg Wissenschaftsverlag
  6. Keywords:
  7. Biodistribution ; Gallium-67 ; Radiolabeling ; Stability ; Superparamagnetic iron oxide nanoparticles
  8. Source: Radiochimica Acta ; Volume 97, Issue 1 , 2009 , Pages 51-56 ; 00338230 (ISSN)
  9. URL: https://www.degruyter.com/view/journals/ract/97/1/article-p51.xml