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Modeling process partitioning of biomolecules in polymer-polymer and polymer-salt aqueous two-phase systems (ATPS) using an extended excess gibbs energy model
Pazuki, G. R ; Sharif University of Technology | 2009
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- Type of Document: Article
- DOI: 10.1524/zpch.2009.5421
- Publisher: 2009
- Abstract:
- A new local composition model was used to study the phase behavior of polymer-polymer and polymer-salt aqueous two-phase systems. The proposed model has three terms which account for the combinatorial, the long-range and the short-range effects in solution. The Flory-Huggins and the Debye-Hückel models were used for the combinatorial and long-range contributions. The interaction parameters of the model studied in this work can be regressed using a non-liner regression between the experimental data and those obtained from the proposed model. Also, this model was applied for modeling the partitioning of biomolecules in polymer-polymer and polymer-salt aqueous two-phase systems. The results showed that the proposed model has a good accuracy in correlating the partitioning coefficients of biomolecules in aqueous two-phase systems. © by Oldenbourg Wissenschaftsverlag, München
- Keywords:
- Aqueous two-phase systems ; Biomolecule ; Gibbs energy model ; Partitioning
- Source: Zeitschrift fur Physikalische Chemie ; Volume 223, Issue 3 , 2009 , Pages 263-278 ; 09429352 (ISSN)
- URL: https://www.degruyter.com/view/journals/zpch/223/3/article-p263.xml