Design and Operation of Proper Freeze Drying Process to Recover Active Biological Agent, M.Sc. Thesis Sharif University of Technology ; Rosta Azad, Reza (Supervisor)
Abstract
One of the most important unit operations in the production of dry powder biological products involves a freeze dryer apparatus. In this process, Liqueur, which is containing the α-amylase enzyme, undergoes a frigidity condition in which loses its moisture during sublimation. Under these circumstances, applying an adequate supply of sublimation enthalpy without raising the temperature of the frigid material up to melting, plays an important role in the quality of the product and preventing degradation of the α-amylase enzyme. Freeze drying depends on two main factors; time and energy. Furthermore, it is necessary to obtain an optimal temperature and pressure for different steps and...
Cataloging briefDesign and Operation of Proper Freeze Drying Process to Recover Active Biological Agent, M.Sc. Thesis Sharif University of Technology ; Rosta Azad, Reza (Supervisor)
Abstract
One of the most important unit operations in the production of dry powder biological products involves a freeze dryer apparatus. In this process, Liqueur, which is containing the α-amylase enzyme, undergoes a frigidity condition in which loses its moisture during sublimation. Under these circumstances, applying an adequate supply of sublimation enthalpy without raising the temperature of the frigid material up to melting, plays an important role in the quality of the product and preventing degradation of the α-amylase enzyme. Freeze drying depends on two main factors; time and energy. Furthermore, it is necessary to obtain an optimal temperature and pressure for different steps and...
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