Motifs are patterns which can be extracted from specific subsequences of promoter region of some related genes. Transcription factor proteins bind to these subsequences and play a significant role in gene expression regulation. Motif discovery is a challenging problem in molecular biology and has been attracting researcher’s attention for years. Different kind of data and computational methods have been used to unravel this problem, but there is still room for improvement. In this study, our goal was to develop a method with the ability to identify all the TFBS signals, including known and unknown, inside the input set of sequences. We developed a clustering method specialized as part...
Motifs are patterns which can be extracted from specific subsequences of promoter region of some related genes. Transcription factor proteins bind to these subsequences and play a significant role in gene expression regulation. Motif discovery is a challenging problem in molecular biology and has been attracting researcher’s attention for years. Different kind of data and computational methods have been used to unravel this problem, but there is still room for improvement. In this study, our goal was to develop a method with the ability to identify all the TFBS signals, including known and unknown, inside the input set of sequences. We developed a clustering method specialized as part...