Simulation of Microcapsule Formation for Cell Encapsulation Application, M.Sc. Thesis Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor) ; Kazemzadeh Hanani, Siamak (Co-Advisor)
Abstract
Co-culture of different cells is necessary for cancer spheroid formation in preclinical drug tests. It is possible to produce thousands of micro-droplets containing different cells, i.e. microcapsules, in a short time, using droplet microfluidics. However the homogeneity of the cell numbers in the droplets has remained as an unsolved problem.Despite the large amount of experimental efforts to reduce the number of undesirable microcapsules, no one tried to utilize the ease of computer aided simulation for investigating different parameters. In this study, we develop a novel method for capturing cell encapsulation using CFD simulations. The effect of the cell suspension inhomogeneity and...
Cataloging briefSimulation of Microcapsule Formation for Cell Encapsulation Application, M.Sc. Thesis Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor) ; Kazemzadeh Hanani, Siamak (Co-Advisor)
Abstract
Co-culture of different cells is necessary for cancer spheroid formation in preclinical drug tests. It is possible to produce thousands of micro-droplets containing different cells, i.e. microcapsules, in a short time, using droplet microfluidics. However the homogeneity of the cell numbers in the droplets has remained as an unsolved problem.Despite the large amount of experimental efforts to reduce the number of undesirable microcapsules, no one tried to utilize the ease of computer aided simulation for investigating different parameters. In this study, we develop a novel method for capturing cell encapsulation using CFD simulations. The effect of the cell suspension inhomogeneity and...
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