Design, Simulation and Fabrication of Human Pulmonary Alveolus Model on a Microchip, Ph.D. Dissertation Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor)
Abstract
Microfluidic systems create great development in diseases and drug delivery in various organs of the body. In this study, human pulmonary alveolar cell performance was evaluated from the perspective of the cell culture using a microfluidic system. For this purpose, numerical simulations of the microchip channels flow field are very important to select appropriate models. So in the first step, the flow field and particle deposition were simulated. Then an optimal model was selected based on key parameters such as cell feeding, shear stress exerted on the cell, particles distribution and also the limitations and possibilities for constructing. The numerical results show that the shear stress,...
Cataloging briefDesign, Simulation and Fabrication of Human Pulmonary Alveolus Model on a Microchip, Ph.D. Dissertation Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor)
Abstract
Microfluidic systems create great development in diseases and drug delivery in various organs of the body. In this study, human pulmonary alveolar cell performance was evaluated from the perspective of the cell culture using a microfluidic system. For this purpose, numerical simulations of the microchip channels flow field are very important to select appropriate models. So in the first step, the flow field and particle deposition were simulated. Then an optimal model was selected based on key parameters such as cell feeding, shear stress exerted on the cell, particles distribution and also the limitations and possibilities for constructing. The numerical results show that the shear stress,...
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