Design and Fabrication of Biodegradable Polymeric Scaffold with nano-Bioglass for Osteoblast cell Growth, M.Sc. Thesis Sharif University of Technology ; Vossoughi, Manouchehr (Supervisor) ; Alemzadeh, Iran (Supervisor) ; Tamjid Shabesteri, Elnaz (Co-Advisor)
Abstract
Treatment of critical-size bone defects caused by sport injuries, accidents, trauma, infection, and osteoporosis remains a major clinical challenge. In order to repair or regenerate large bone defects, bioactive three-dimensional scaffolds play a key role due to their multilevel porous structure, high surface area, enhanced mass transport and diffusion. Many studies reported that macropore diameters greater than 500 µm can lead to vascularized bone tissue. In this study, a hierarchically porous composite scaffold was prepared. Hierarchically porous silk fibroin- bioactive glass composite and fibroin scaffold were fabricated with controlled architecture and interconnected structure with...
Cataloging briefDesign and Fabrication of Biodegradable Polymeric Scaffold with nano-Bioglass for Osteoblast cell Growth, M.Sc. Thesis Sharif University of Technology ; Vossoughi, Manouchehr (Supervisor) ; Alemzadeh, Iran (Supervisor) ; Tamjid Shabesteri, Elnaz (Co-Advisor)
Abstract
Treatment of critical-size bone defects caused by sport injuries, accidents, trauma, infection, and osteoporosis remains a major clinical challenge. In order to repair or regenerate large bone defects, bioactive three-dimensional scaffolds play a key role due to their multilevel porous structure, high surface area, enhanced mass transport and diffusion. Many studies reported that macropore diameters greater than 500 µm can lead to vascularized bone tissue. In this study, a hierarchically porous composite scaffold was prepared. Hierarchically porous silk fibroin- bioactive glass composite and fibroin scaffold were fabricated with controlled architecture and interconnected structure with...
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