Loading...

Remote trice light, temperature, and pH-actuation of switchable magneto-plasmonic nanocarriers for combinational photothermal and controlled/targeted chemotherapies

Hadilou, N ; Sharif University of Technology | 2018

734 Viewed
  1. Type of Document: Article
  2. DOI: 10.1016/j.xphs.2018.08.021
  3. Publisher: Elsevier B.V , 2018
  4. Abstract:
  5. Three magneto-plasmonic nanohybrids were synthesized using Au- and Ag-coated Fe3O4 nanoparticles (NPs)-modified dual pH- and temperature-responsive triblock copolymer of poly (butyl methacrylate-co-acrylamide-co-methacrylic acid) to serve as drug carriers with potential of using in both photothermal and controlled/targeted chemotherapies. The internal superparamagnetic core gives the carriers targeted-delivery characteristics, and surface plasmon resonance–based noble metallic Au/Ag shells give them on-demand photothermal and photo-triggering release properties. To investigate the effect of coating method on the targeting property of synthesized carriers, Au NPs were attached to the magnetic core by 2 different direct/indirect procedures and the properties of the synthesized carriers including swelling ratio and thermal and optical sensitivity and switching were comprehensively investigated in 2 different buffer solutions with pH 5.5 and 7.4 at 37°C. Letrozole was used as a model anticancer drug and its loading and release properties were evaluated for the four nanocarriers. The cytotoxicity of drug-free and letrozole-loaded nanocarriers on normal L929 fibroblast and MDAMB 231 breast cancer cell lines was evaluated in absence/presence of laser radiation. The results revealed that the carriers have the potential of serving as switchable trimodal light/temperature/pH-triggered and targeted/controlled drug delivery platforms for chemophotothermal therapy. © 2018 American Pharmacists Association®
  6. Keywords:
  7. Chemophotothermal therapy ; Laser-enhanced release ; Magneto-plasmonic nanoparticles ; Responsive polymers ; switchable drug release
  8. Source: Journal of Pharmaceutical Sciences ; Volume 107, Issue 12 , 2018 , Pages 3123-3133 ; 00223549 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/pii/S0022354918305227