Investigating the Effect of Geometric Shape and Properties of Protein Corona on Drug Release Using Finite Element Method, M.Sc. Thesis Sharif University of Technology ; Naghdabadi, Reza (Supervisor)
Abstract
In novel drug delivery systems, once nanocarriers confront the biological milieu, their surface is rapidly covered with a layer of biomolecules (i.e., “protein corona”) which play an important role in their drug release rate. Various experimental studies have been done to elucidate the effect of nanoparticles properties on the drug release rate in different biological applications. The physical and geometrical properties of protein corona totally influence on the release profile. In this study, we proposed a suitable finite element model which contains the nanoparticles and the protein layer with their properties in the biological milieu. To this end, diffusion parameters including diffusion...
Cataloging briefInvestigating the Effect of Geometric Shape and Properties of Protein Corona on Drug Release Using Finite Element Method, M.Sc. Thesis Sharif University of Technology ; Naghdabadi, Reza (Supervisor)
Abstract
In novel drug delivery systems, once nanocarriers confront the biological milieu, their surface is rapidly covered with a layer of biomolecules (i.e., “protein corona”) which play an important role in their drug release rate. Various experimental studies have been done to elucidate the effect of nanoparticles properties on the drug release rate in different biological applications. The physical and geometrical properties of protein corona totally influence on the release profile. In this study, we proposed a suitable finite element model which contains the nanoparticles and the protein layer with their properties in the biological milieu. To this end, diffusion parameters including diffusion...
Find in contentBookmark |
|