Investigating the Effects of DBS on Brain Connectivity by Causal Inference in Parkinson’s Disease, M.Sc. Thesis Sharif University of Technology ; Rabiee, Hamid Reza (Supervisor)
Abstract
Parkinson’s disease (PD) is a progressive debilitating neurological disorder that causes motor and cognitive impairment. Administration of dopaminergic medication (Levodopa) has been reported to be effective in attenuating the excessive pathological synchronization in basal ganglia. However, long term levodopa therapy has its pitfalls. High frequency deep brain stimulation (DBS) has been suggested as an effective alternative for reducing motor symptoms in PD. In this method, distinct brain regions involved in the pathophysiology of the disease are stimulated electrically at high frequencies (i.e. at 130 Hz). While several studies have been carried out on the effects of DBS and its clinical...
Cataloging briefInvestigating the Effects of DBS on Brain Connectivity by Causal Inference in Parkinson’s Disease, M.Sc. Thesis Sharif University of Technology ; Rabiee, Hamid Reza (Supervisor)
Abstract
Parkinson’s disease (PD) is a progressive debilitating neurological disorder that causes motor and cognitive impairment. Administration of dopaminergic medication (Levodopa) has been reported to be effective in attenuating the excessive pathological synchronization in basal ganglia. However, long term levodopa therapy has its pitfalls. High frequency deep brain stimulation (DBS) has been suggested as an effective alternative for reducing motor symptoms in PD. In this method, distinct brain regions involved in the pathophysiology of the disease are stimulated electrically at high frequencies (i.e. at 130 Hz). While several studies have been carried out on the effects of DBS and its clinical...
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