Fabrication and Characterization of Bioactive PLGA- TiO2 Nanocomposite Scaffold by Air-liquid Foaming for Bone Tissue Engineering, Ph.D. Dissertation Sharif University of Technology ; Madaah Hosseini, Hamid Reza (Supervisor) ; Samadi Kuchaksaraei, Ali (Co-Supervisor)
Abstract
Poly (lactate-co-glycolate) is a typical biocompatible and biodegradable synthetic polymer. Addition of TiO2 nanoparticles improved compressive modulus of PLGA scaffolds and reduced fast degradation. Porous 3D scaffolds, which are synthesized using biocompatible and biodegradable materials, could provide suitable microenvironment and mechanical support for optimal cell growth and function. A novel method has been applied to fabricate PLGA/TiO2 scaffolds without using any organic solvent or porogen for nucleation compared to former ways, with aim of improving the biocompatibility, macroscale morphology and well inter-connected pores efficacy: Air-Liquid Foaming. Adjustment of the foaming...
Cataloging briefFabrication and Characterization of Bioactive PLGA- TiO2 Nanocomposite Scaffold by Air-liquid Foaming for Bone Tissue Engineering, Ph.D. Dissertation Sharif University of Technology ; Madaah Hosseini, Hamid Reza (Supervisor) ; Samadi Kuchaksaraei, Ali (Co-Supervisor)
Abstract
Poly (lactate-co-glycolate) is a typical biocompatible and biodegradable synthetic polymer. Addition of TiO2 nanoparticles improved compressive modulus of PLGA scaffolds and reduced fast degradation. Porous 3D scaffolds, which are synthesized using biocompatible and biodegradable materials, could provide suitable microenvironment and mechanical support for optimal cell growth and function. A novel method has been applied to fabricate PLGA/TiO2 scaffolds without using any organic solvent or porogen for nucleation compared to former ways, with aim of improving the biocompatibility, macroscale morphology and well inter-connected pores efficacy: Air-Liquid Foaming. Adjustment of the foaming...
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