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Cysteic acid grafted to magnetic graphene oxide as a promising recoverable solid acid catalyst for the synthesis of diverse 4H-chromene

Matloubi Moghaddam, F ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.1038/s41598-020-77872-8
  3. Publisher: Nature Research , 2020
  4. Abstract:
  5. 4H-chromenes play a significant role in natural and pharmacological products. Despite continuous advances in the synthesis methodology of these compounds, there is still a lack of a green and efficient method. In this study, we have designed cysteic acid chemically attached to magnetic graphene oxide (MNPs·GO-CysA) as an efficient and reusable solid acid catalyst to synthesize 4H-chromene skeletons via a one-pot three components reaction of an enolizable compound, malononitrile, an aldehyde or isatin, and a mixture of water–ethanol as a green solvent. This new heterogeneous catalyst provides desired products with a good to excellent yield, short time, and mild condition. This procedure presents an environmentally friendly approach for the synthesis of a great number of 4H-chromene derivatives. © 2020, The Author(s)
  6. Keywords:
  7. Magnetic graphene oxide ; 4H-chromenes ; Cysteic acid ; Graphene Oxide ; Solid acid catalyst ; Green Chemistry
  8. Source: Scientific Reports ; Volume 10, Issue 1 , December , 2020
  9. URL: https://www.nature.com/articles/s41598-020-77872-8