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Ag-doped magnetic metal organic framework as a novel nanostructured material for highly efficient antibacterial activity

Rahmati, Z ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.1016/j.envres.2020.109555
  3. Publisher: Academic Press Inc , 2020
  4. Abstract:
  5. In the last decades, numerous attempts have been made to prevent microbial pollution spreading, using antibacterial agents. Zeolitic imidazolate framework-8 (ZIF-8) belongs to a subgroup of metal organic frameworks (MOFs) merits of attention due to the zinc ion clusters and its effective antibacterial activity. In this work, Ag-doped magnetic microporous γ-Fe2O3@SiO2@ZIF-8-Ag (FSZ-Ag) was successfully synthesized by a facile methodology in room temperature and used as an antibacterial agent against the growth of the Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacteria. Several characterization methods were applied to analyze the properties of the materials, and the results confirmed the accuracy of the synthesis procedure. Silver ions have employed to enhance the efficiency of antibacterial activity. As the results illustrated, FSZ-Ag nanostructured material had superior performance to inactive E. coli and S. aureus in growth inhibition test in liquid media. The best antibacterial activity as minimum inhibitory concentration (MIC) was 100 mg/L of FSZ-Ag against both bacteria. Leaching rates of silver ions showed that 80% of Ag released in the solutions, which was responsible for inhibiting the growth of bacteria. Also, fluorescence microscopy was used to investigate bacterial viability after 20 h contacting FSZ-Ag to distinguish live and dead bacteria by staining with DAPI and PI fluorescence stains. This novel magnetic nanostructured material is an excellent promising candidate to use in biological applications as high potential bactericidal materials. © 2020 Elsevier Inc
  6. Keywords:
  7. Antibacterial activity ; Magnetic nanostructured material ; Silver doping ; ZIF-8 ; Imidazole derivative ; Silica nanoparticle ; Silver ; Silver nanoparticle ; Ultrasmall superparamagnetic iron oxide ; Zeolite ; Antiinfective agent ; Metal nanoparticle ; Nanomaterial ; Silicon dioxide ; Antimicrobial activity ; Bacterium ; Magnetic method ; Nanoparticle ; Organometallic compound ; Antibacterial activity ; Bacterial growth ; Bacterial viability ; Controlled study ; Drug synthesis ; Energy dispersive X ray spectroscopy ; Escherichia coli ; Fluorescence microscopy ; Fourier transform infrared spectroscopy ; Growth inhibition ; Inductively coupled plasma atomic emission spectrometry ; Leaching ; Minimum inhibitory concentration ; Nonhuman ; Priority journal ; Room temperature ; Staphylococcus aureus ; X ray diffraction ; Magnetism ; Microbial sensitivity test ; Bacteria (microorganisms) ; Escherichia coli ; Negibacteria ; Posibacteria ; Anti-Bacterial Agents ; Escherichia coli ; Magnetic Phenomena ; Metal Nanoparticles ; Metal-Organic Frameworks ; Microbial Sensitivity Tests ; Nanostructures ; Metal organic framework
  8. Source: Environmental Research ; Volume 188 , 2020
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0013935120304485