Asymptotic Analysis and Optimal Control of an Integro-Differential System Modeling Healthy and Cancer Cells Exposed to Chemotherapy

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Vosooq Nejad, Parisa | 2020

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 53291 (02)
University: Sharif University of Technology
Department: Mathematical Sciences
Advisor(s): Hesaraki, Mahmoud
Abstract:
We consider a system of two coupled integro-differential equations modelling populations of healthy and cancer cells under chemotherapy. Both populations are structured by a phenotypic variables, representing their level of resistance to the treatment. we analyse the asymptotic behaviour of the model under constant infusion of drugs. By designing an appropriate Lyapunov function, we prove that both cell densities converge to Dirac masses. We then define an optimal control problem, by considering all possible infusion protocols and minimising the number of cancer cells over a prescribed time frame. We provide a quasi-optimal strategy and prove that it solves this problem for large final times. For this modelling framework, we illustrate our results with numerical simulations, and compare our optimal strategy with periodic treatment schedules
Keywords:
Optimal Control ; Integral Differential Equations ; Asymptotic Behavior ; Cancer Chemotherapy ; Mathematical Oncology

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