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Computational Study on the Evaluation of Antihemophilic Factors Effect on Clot Formation

Barzegar, Saeed | 2020

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 53308 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Assempour, Ahmad; Ahmadian, Mohammad Taghi
  7. Abstract:
  8. Many heart attacks and strokes are caused by improper clot formation in the vascular system. Mathematical understanding of the clot formation process and the influence of various factors in the clot formation process is very important. In this study, the aim is to simulate and understand the clotting process mathematically by considering natural, external and general mechanisms in the clotting process. In this process, when damage occurs in the endothelial region of the vessel, tissue factor is released and 38 different substances react with each other inside the plasma, eventually forming fibrin. To simulate the movement of different chemical components and proteins in plasma, the concentration equation along with its reactive part has been used. The momentum and continuity equation are used to move the blood. Fibrin tissue is considered to be porous with variable permeability, with areas near the endothelium having less permeability, and the closer we get to the clot surface, the lower the permeability. The hydrodynamic resistance of fibrin is not so great as to resist the fluid convection, so four different types of platelets have been considered, some of which are activated by thrombin and adenosine diphosphate and adhere to the endothelial region and network tissue such as fibrin, causing the generalized permeability reduction and the fibrin formed in the intra-fluid state remain stable. 10 Boundary conditions on the affected area are considered as first-order linear differential equations. In order to balance the mass on the natural components of the plasma, this term is included as a flux in the natural components of the plasma. Finally, the production of thrombin and fibrin has been investigated for different amounts of the VIII and IX factors. Also, as a treatment method in hemophilia patients, the effect of increasing the VIIa factor has been considered as a replacement for the deficiency of antihaemophilia factors
  9. Keywords:
  10. Thrombosis Formation ; Haemophilia ; Fibrin Gel ; Convection-Diffusion-Reaction Equations ; Stroke ; Zymogen

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