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Design and Synthesis of Self-healing Gels Based on Natural Polysaccharides Using Reversible Bonds and Investigations of their Applications

Tavakolizadeh, Maryam | 2021

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  1. Type of Document: Ph.D. Dissertation
  2. Language: Farsi
  3. Document No: 53678 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Pourjavadi, Ali
  7. Abstract:
  8. In recent years, burns and deep wounds that occur in various accidents are important reasons of death in the world. Therefore, the healing process of burn and full thickness of wounds due to late treatment has always been considered by physicians. Thus, the correct treatment and speed of healing of these types of wounds have always been studied. Many synthetic and natural materials have been used to treat wounds, which among them, hydrogels have received a great attention due to creating a moist environment for wounds and absorbing secretions. However, external mechanical stresses may degrade the therapeutic hydrogel. Recently, self-healing coating hydrogels have been designed and developed that have the ability to repair their three-dimensional structure after destruction, increasing their lifespan. Covalent and non-covalent reversible bonds have been used in the hydrogel structure to obtain the desired self-healing property. However, due to the reversible nature of these bonds, most self-healing therapeutic hydrogels suffer from poor mechanical strength. In addition, due to the lack of adhesion, most of these hydrogels cannot interact strongly with wound tissue. Consequently, in addition to self-healing, mechanical strength and tissue adhesion must be considered to design hydrogel therapies. In this study, self-healing hydrogels based on natural polysaccharides were prepared. In order to create self-healing ability in the structure of these hydrogels, reversible imine bonds (Schiff-base) were used to increase the mechanical strength and the second network with physically or chemically reversible bonds was entered into the hydrogel structure. The combination of two reversible and non-reversible networks in the hydrogel structure along with plant extract (healing agent) and silver nanoparticles (antibacterial agent) provided a suitable substrate for the treatment of various wounds, especially burn and full thickness wounds
  9. Keywords:
  10. Double Network Hydrogel ; Self Healing System ; Wound Dressing ; Schiff-Base Interaction ; Natural Polysaccharides ; Self Healing Hydrogel

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