Design and Fabrication of a Microfluidic Device for the Formation of Multicellular Aggregates and Using in Tissue Engineering, Ph.D. Dissertation Sharif University of Technology ; Shamloo, Amir (Supervisor) ; Kazemzadeh, Siamak (Supervisor)
Abstract
Three-dimensional cell culture and forming multicellular aggregates is superior over traditional monolayer approaches due to better mimicking in vivo conditions and hence functions of a tissue. A considerable amount of attention has been devoted to devising efficient methods for the rapid formation of uniform sized multicellular aggregates. Restoring cartilage to healthy state is difficult due to low cell density and hence low regenerative capacity. Currently used platforms are not compatible with clinical translation and require dedicated handling of trained personnel. However, when engineering and implanting cell microaggregates in a higher concentration, new cartilage is efficiently...
Cataloging briefDesign and Fabrication of a Microfluidic Device for the Formation of Multicellular Aggregates and Using in Tissue Engineering, Ph.D. Dissertation Sharif University of Technology ; Shamloo, Amir (Supervisor) ; Kazemzadeh, Siamak (Supervisor)
Abstract
Three-dimensional cell culture and forming multicellular aggregates is superior over traditional monolayer approaches due to better mimicking in vivo conditions and hence functions of a tissue. A considerable amount of attention has been devoted to devising efficient methods for the rapid formation of uniform sized multicellular aggregates. Restoring cartilage to healthy state is difficult due to low cell density and hence low regenerative capacity. Currently used platforms are not compatible with clinical translation and require dedicated handling of trained personnel. However, when engineering and implanting cell microaggregates in a higher concentration, new cartilage is efficiently...
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