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Blood Glucose Control for Type 1 Diabetes Patients with Explicit Model Predictive Control (MPC)

Shahzadeh Fazeli, Ali | 2021

2008 Viewed
  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 54007 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Alasty, Aria; Vahidi, Omid
  7. Abstract:
  8. Blood glucose regulation in type 1 diabetes patients requires the delivery of the proper amount of insulin from an external source. The literature of Blood Glucose Control signifies the superiority of model-based controllers over the other ones. Regarding its lack of need to complicated on-line calculations and the simplicity of its implementation on a micro-chip, the explicit Model Predictive Controller is preferred over the implicit MPC. Currently proposed explicit MPC controllers have employed relatively simple models representing human glucose-insulin dynamics. In this thesis, an explicit MPC controller is designed using mp-QP based on Sorensen’s 19-state comprehensive model which has been linearized around a suitable equilibrium point. Therefore, the system’s working space is partitioned into critical regions, and a specific explicit control law is derived for each of them as a function of the states. The system’s control input is the continuous insulin infusion rate provided by an insulin pump and its outputs are peripheral blood glucose and insulin concentrations. The main purpose of the controller is to track the system’s outputs to their corresponding equilibrium values. Computer simulation demonstrated that the blood glucose concentration of the diabetic patient controlled by this explicit MPC controller was similar to that of a healthy person, even after eating the largest meal mentioned in the literature. In addition, comparing the performance of the explicit MPC controller designed based on Sorensen’s model and the explicit MPC controller designed based on the Bergman’s model displays the superiority of the explicit MPC controller designed based on Sorensen’s model
  9. Keywords:
  10. Diabetes Mellitus Type 1 ; Blood Glucose ; Meal Disturbance ; Explicit Model Based Predictive Controller (MPC) ; Blood Glucose Control ; Sorensen’s Model

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