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Study on the Performance of Magnetic Nanoparticles in Hyper-thermic Treatment of Cancerous Tumors, by Heating an MRI Apparatus

Payami Golhin, Zahra | 2021

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 54580 (46)
  4. University: Sharif University of Technology
  5. Department: Energy Engineering
  6. Advisor(s): Outokesh, Mohammad; Nourani, Mohammad Reza
  7. Abstract:
  8. The aim of this study was to investigate the rate of increase in temperature of a phantom equivalent to body tissue by different groups of magnetic iron nanoparticles in the external magnetic field to kill cancer cells based on the hyperthermia method. To achieve this goal, three groups of dextran magnetic nanoparticles with different properties and reduced iron oxide-graphene oxide magnetic nanoparticles by M-rGO supercritical synthesis method were used. After XRD, FTIR, SEM, FESEM, VSM, TEM characterization tests, these materials were placed in a phantom made of agarose gel and with the same properties, in a magnetic field with fixed characteristics for all groups and during the process of magnetic fluid hyperthermia, the rate of increase in ambient temperature of these particles was obtained. Then, MTT test was performed on two nanoparticle models that had the best performance in last test and was injected into three mices with subcutaneous fibroblast and after applying the magnetic fluid hyperthermia process, the function of each nanoparticle was recorded in in-vivo environment.The results of in-vitro hyperthermia process on mice showed that the reduced iron oxide-graphene oxide magnetic nanoparticles by M-rGO supercritical synthesis method according to the information obtained from characterization tests and in-vitro hyperthermia stage as well as non-toxicity in MTT and Excellent thermal performance in the body is a good material for more extensive research on other malignant and inaccessible cancers, such as glioblastoma brain cancer
  9. Keywords:
  10. Superparamagnetic Nanoparticles ; Cancer ; Magnetic Nanodot ; In-Vivo Sampling ; In-Vitro Biological Assays ; Hyperthermia Magnetic Particles ; Hyperthermia Method ; Radio Frequencies ; Magnetic Rron Oxide-Reduced Graphene Oxide

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