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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 54591 (06)
- University: Sharif University of Technology
- Department: Chemical and Petroleum Engineering
- Advisor(s): Saadatmand, Maryam; Eskandari, Mahnaz
- Abstract:
- Microfluidic systems have the ability to produce microgels with uniform size distribution and spherical shape due to the laminar flow and better control of the flow rates. Spherical microgels with same size can be used as high-potential carriers for drug release. An important challenge in the production of these drug-carrying microgels is the simultaneous process of drug loading into microgels and their production. The overall goal of this project was to produce drug-carrying microgels with uniform size distribution that show controlled drug release. To achieve this goal, various factors such as the type of polymer, the type of drug, the volume ratio of the polymer and the drug and the geometry of the microfluidic system used can be effective in addressing these challenges.In this study, a stream-focused microfluidic chip containing a coating current was used to prevent chip clogging. Alginate oxide was synthesized with 30% oxidation percentage and then alginate, alginate oxide and combinations of alginate oxide and gelatin with volume ratios of 50-50 ,70-30 and 30-70, by determining their appropriate weight percentage, were used for controlled release of letrozole. The chemical properties of microgels such as FTIR and the optimal sample of polymers were determined and after confirming that the chemical structure was obtained, physical properties such as SEM, swelling ratio and stability were investigated. According to the SEM results, the level of alginate and gelatin composition had different heterogeneity and folds, and according to the results, the swelling and stability ratio of these compounds had less swelling and more stability, which was important in controlling the release.Examination of microgels showed that microgels made of alginate-gelatin oxide with volume ratios of 30-70 had a good morphology, swelling ratio and structural stability. After loading letrozole, drug release tests, loading percentage and release kinetics were measured. The percentage of drug loading and drug release in 13 days for the combination of alginate and gelatin with a volume ratio of 70-30 had a yield of 70% and release of 50%, respectively, compared to alginate, alginate oxide, and a combination of alginate and gelatin with a volume ratio of 50-50 And 30-70, which were loading in the range of 50-60% and drug release in the range of 60% -90%, respectively, have high yields and release. Examining the drug release profile, it was concluded that drug release follows the Higuchi model and therefore follows the law of penetration. According to the results of the mentioned tests, the combination of alginate and gelatin with a volume ratio of 30-70 is a suitable percentage combination for letrozole loading and drug release because it has the results of proper swelling and stability ratio and high loading percentage, low release percentage and is controlled. Examining the drug release profile, it was concluded that drug release follows the Higuchi model and therefore follows the Fick law. According to the results of the mentioned tests, the combination of ADA and gelatin with a volume ratio of 30-70 is a suitable percentage combination for letrozole loading and drug release because it has the results of proper swelling and stability ratio and high loading percentage, low release percentage and is controlled
- Keywords:
- Microgel ; Gelatin ; Drug Release ; Oxidized Alginate ; Flow Focusing Device ; Microfluidic Chip ; Letrozole ; Shielding Flow
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