Loading...

Fabrication of carboxymethyl chitosan/poly(ε-caprolactone)/doxorubicin/nickel ferrite core-shell fibers for controlled release of doxorubicin against breast cancer

Abasalta, M ; Sharif University of Technology | 2021

691 Viewed
  1. Type of Document: Article
  2. DOI: 10.1016/j.carbpol.2021.117631
  3. Publisher: Elsevier Ltd , 2021
  4. Abstract:
  5. The coaxial electrospinning for producing core-shell nanofibers due to control the release profile of drug by the shell layer has been developed. N-carboxymethyl chitosan (CMC)-polyvinyl alcohol (core)/poly(ε-caprolactone) (PCL) (shell) nanofibers were produced via coaxial electrospinning. Doxorubicin (DOX) and nickel ferrite nanoparticles were incorporated into the nanofibers for controlled release of DOX against MCF-7 breast cancer. The minimum CMC/PCL fiber diameter was found to be 300 nm by optimizing of three variables including voltage to distance ratio (1.5–2.5 kV/cm), CMC concentration (4−6 wt.%) and PCL concentration (8−12 wt.%). The synthesized core-shell fibers were characterized using FTIR, XRD, SEM, and TEM analysis. The extended release and controlled release of DOX from core-shell nanofibers were achieved under physiological pH without external magnetic field (EMF) and acidic pH with EMF during 25 and 7 days, respectively. The maximum cytotoxicity of MCF-7 breast cancer cells was about 83 % using CMC/PCL/nickel ferrite 10 % nanofibers and EMF. © 2021
  6. Keywords:
  7. Chitosan ; Diseases ; Electrospinning ; Ferrite ; Magnetic nanoparticles ; Nanofibers ; Shells (structures) ; Targeted drug delivery ; Carboxymethyl chitosan ; Coaxial electrospinning ; Controlled release ; Core-shell nanofibers ; External magnetic field ; MCF-7 breast cancer cells ; N-carboxymethyl chitosans ; Nickel ferrite nanoparticle ; Controlled drug delivery ; Antineoplastic agent ; Carboxymethyl-chitosan ; Doxorubicin ; Ferric ion ; Metal nanoparticle ; Nanofiber ; Nickel ; Nickel ferrite ; Polycaprolactone ; Polyester ; Breast tumor ; Chemistry ; Delayed release formulation ; Drug delivery system ; Drug release ; Drug screening ; Female ; Human ; Magnetic field ; MCF-7 cell line ; PH ; Antineoplastic Agents ; Breast Neoplasms ; Delayed-Action Preparations ; Drug Delivery Systems ; Drug Liberation ; Drug Screening Assays, Antitumor ; Ferric Compounds ; Humans ; Hydrogen-Ion Concentration ; Magnetic Fields ; MCF-7 Cells ; Metal Nanoparticles ; Polyesters
  8. Source: Carbohydrate Polymers ; Volume 257 , 2021 ; 01448617 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0144861721000199