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Adsorption and sustained release of doxorubicin from N-carboxymethyl chitosan/polyvinyl alcohol/poly(ε-caprolactone) composite and core-shell nanofibers

Abasalta, M ; Sharif University of Technology | 2021

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  1. Type of Document: Article
  2. DOI: 10.1016/j.jddst.2021.102937
  3. Publisher: Editions de Sante , 2021
  4. Abstract:
  5. The core-shell nanofibers, produced by the coaxial electrospinning method, are good candidates for delivery of anticancer drugs due to their continuous release without initial burst release. In this work, the N-carboxymethyl chitosan (N-CMCS)-polyvinyl alcohol (PVA)/poly(ε-caprolactone) (PCL) composite and core-shell nanofibers were prepared by two-nozzle and coaxial electrospinning techniques, respectively. Doxorubicin (DOX) as an anticancer drug was loaded into the N-CMCS/PVA/PCL nanofibers fabricated by two-nozzle and coaxial electrospinning. The performance of nanofibers was compared for the adsorption and controlled release of DOX against MCF-7 breast cancer cells death in vitro. The produced fibers were characterized using FTIR, SEM, and TEM analysis. Drug encapsulation efficiency, drug content, and drug release studies were evaluated. The DOX molecules were released from coaxial nanofibers without burst release under extended-release during 20, and 10 days under pH values of 7.4 and 5.5, respectively. The initial burst release at the first hours following by the sustained release of DOX was achieved for composite nanofibers during 11 and 3 days under physiological and acidic pH, respectively. The maximum monolayer sorption capacities of N-CMCS/PVA/PCL composite and core-shell nanofibers for DOX sorption were 74.31 and 40.74 mg g−1, respectively at optimum pH of 8, equilibrium times of 60 min (composite nanofibers) and 120 min (core-shell nanofibers). The maximum MCF-7 breast cancer cells death was about 57% in the presence of DOX loaded-coaxial nanofibers after 7 days. The obtained results demonstrated the high potential of coaxial nanofibers compared with composite nanofibers for drug delivery of anticancer drugs. © 2021 Elsevier B.V
  6. Keywords:
  7. Core-shell fibers ; Poly(ε-caprolactone) ; N-carboxymethyl chitosan ; MCF-7 breast cancer ; Doxorubicin
  8. Source: Journal of Drug Delivery Science and Technology ; 2021 ; 17732247 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S1773224721006171