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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 54610 (08)
- University: Sharif University of Technology
- Department: Mechanical Engineering
- Advisor(s): Asempour, Ahmad; Ahmadian, Mohamadtaghi
- Abstract:
- Cancer is the second leading cause of death in the world, with a high annual cost of treatment. As the cancer progresses, the cancer cells in the bloodstream metastasize to other parts of the body, causing the disease to spread throughout the patient's body and disrupt organ functions. sepration of cancer cells in the bloodstream inhibits the growth of cancer. Cancer cells differ from healthy cells in some features, such as size, electrical charge and polarization. These features can be used to seprate cancer cells from healthy cells.In this study, cell surface electrical charge was used as a biomarker to seprate cancer cells. By passing blood flow through a chanal and applying an electrical field, the cancer cells that carry the negative surface electrical charge are deflected to one side of the chanal, and by separating the flow, the cancer cells can be separated from the bloodstream. The functional parameters in this study are the electrical field and the flow rate of blood flow through the chanal.Cancer cells have different size, density and surface electrical charge. To seprate all cancer cells, a critical cancer cell was introduced and its characteristics were obtained. Numerical calculations and simulations were performed to isolate critical cancer cells for electric fields, different discharges, and the possibility of seprating cancer cells from the whole blood of the cancer patient
- Keywords:
- Cancer Cells ; Biomarker ; Cancer ; Electrical Field ; Circulating Tumor Cells (CTC) ; Cell Surface Charge ; Cancer Cell Sepration
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