Synthesis and Characterization of Dextran Based Magnetic Nanogels as a Gene Delivery Vector and Investigating its Gene Therapy Efficiency, M.Sc. Thesis Sharif University of Technology ; Madaah Hosseini, Hamid Reza (Supervisor) ; Arefian, Ehsan (Supervisor)
Abstract
The use of magnetic nanoparticles modified with proper surface agent and the ability of controlling by magnetic field, that can induce colloidal stability, is considered as a vector to transfer DNA plasmid, or pDNA in short, in the field of gene therapy. In thiss research, pH-responsive dextran-based magnetic nanogels (dextMNGs) were synthesized via inverse mini-emulsion method. Fourier transformation infrared spectroscopy (FTIR) showed that magnetite nanoparticles (MNPs) were successfully modified with arginine and had amine terminals. FTIR, also, proved that aldehyded dextran was crosslinked by arginine modified magnetite nanoparticles (RMNPs) via pH sensitive imine bonds. X-ray...
Cataloging briefSynthesis and Characterization of Dextran Based Magnetic Nanogels as a Gene Delivery Vector and Investigating its Gene Therapy Efficiency, M.Sc. Thesis Sharif University of Technology ; Madaah Hosseini, Hamid Reza (Supervisor) ; Arefian, Ehsan (Supervisor)
Abstract
The use of magnetic nanoparticles modified with proper surface agent and the ability of controlling by magnetic field, that can induce colloidal stability, is considered as a vector to transfer DNA plasmid, or pDNA in short, in the field of gene therapy. In thiss research, pH-responsive dextran-based magnetic nanogels (dextMNGs) were synthesized via inverse mini-emulsion method. Fourier transformation infrared spectroscopy (FTIR) showed that magnetite nanoparticles (MNPs) were successfully modified with arginine and had amine terminals. FTIR, also, proved that aldehyded dextran was crosslinked by arginine modified magnetite nanoparticles (RMNPs) via pH sensitive imine bonds. X-ray...
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