Selective Transfection of Smart Polymeric Nanoparticles Into Reactive Astrocytes in Animal Model of Spinal Cord Injury, Ph.D. Dissertation Sharif University of Technology ; Frounchi, Masoud (Supervisor) ; Mashayekhan, Shohreh (Co-Supervisor) ; Kiani, Sahar (Co-Supervisor)
Abstract
In this study, chitosan-based nanoparticles were prepared due to their biocompatibility, availability, high loading capacity of drug, stimulus responsive behavior and the presence of active functional groups. Chitosan was chemically functionalized with reactive oxygen species (ROS)-responsive moiety to respond to the oxidative stess and endosomal pH in nerve injuries. To prepare nanoparticles, functinalized chitosan ionically gelated with pH-responsive polyanions with ROS-scavenging properties such as polyacrylic acid and hyaluronic acid. Then, pH- and ROS-responsive nanoparticles were used for selective transfection into reactive astrocytes and axonal regeneration in spinal cord injuries....
Cataloging briefSelective Transfection of Smart Polymeric Nanoparticles Into Reactive Astrocytes in Animal Model of Spinal Cord Injury, Ph.D. Dissertation Sharif University of Technology ; Frounchi, Masoud (Supervisor) ; Mashayekhan, Shohreh (Co-Supervisor) ; Kiani, Sahar (Co-Supervisor)
Abstract
In this study, chitosan-based nanoparticles were prepared due to their biocompatibility, availability, high loading capacity of drug, stimulus responsive behavior and the presence of active functional groups. Chitosan was chemically functionalized with reactive oxygen species (ROS)-responsive moiety to respond to the oxidative stess and endosomal pH in nerve injuries. To prepare nanoparticles, functinalized chitosan ionically gelated with pH-responsive polyanions with ROS-scavenging properties such as polyacrylic acid and hyaluronic acid. Then, pH- and ROS-responsive nanoparticles were used for selective transfection into reactive astrocytes and axonal regeneration in spinal cord injuries....
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