Design and Implementation of an Optical Intrinsic Signal Imaging System for Brain by Using Intensity Magnification Algorithm

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Alemohammad, Mohammad Amin | 2021

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 54717 (05)
University: Sharif University of Technology
Department: Electrical Engineering
Advisor(s): Fardmanesh, Mahdi; Ghazizadeh Ehsaee, Ali
Abstract:
In many neuroscience studies, the aim is to investigate the functional role of a population of neurons in response to a certain stimulus. Electrophysiology methods usually can only record from a small population of neurons and this is not sufficient for studying functional properties of the cortex. An alternative is to use functional neuroimaging methods. However, some of these methods are expensive and also they do not offer suitable spatial and temporal resolutions. Optical imaging systems can solve these problems because they are low-cost, easy to design, and also have good temporal and spatial resolutions. These systems can generate functional maps from the brain. In this study, a low-cost optical imaging system based on intrinsic signals was designed and implemented. The system was tested on rats for performance evaluation. Hemodynamic response was successfully extracted and the activated brain regions were detected too. To analyze images even more, Eulerian intensity magnification was used and it was observed that by using this method some of the activities that are not normally detectable could be detecte
Keywords:
Optical Imaging ; Hemodynamics ; Intensity Magnification ; Hemodynamic Response ; Barrel Cortex ; Functional Mapping ; Intrinsic Brain Signal

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