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Preparation of Host-Guest Hydrogels Responsive to Environmental Stimuli based on Diazo Compounds for Drug Release

Yousefi Adlsadabad, Samaneh | 2022

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 54796 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Pourjavadi, Ali
  7. Abstract:
  8. Conventional chemotherapy methods impact both normal and cancerous cells; therefore, it is essential to design novel drug delivery systems in order to reduce drugs’ side effects. Having high retention time in blood and the capability of crossing blood-brain barriers are the characteristics of nano-scaled drug delivery systems.The research thesis is about the synthesis and characterization of the light-sensitive biocompatible nanogels with the core-shell structure with the intention of Doxorubicin anti-cancer drug delivery. These smart nanogels possess a hydrophobic core coated with hydrophilic starch polymeric chain modified with beta-cyclodextrin. The formation of the core-shell structure is based on host-guest interaction between Azobenzene and beta-cyclodextrin moieties. In this study, we have investigated the role of Azobenzene molecule as a photochromic constituent. The mechanism of drug release is based on the isomerization of Azobenzene molecule upon Ultraviolet light irradiation (365 nm). In other words, the drug release not only could be accelerated by the removal of hydrophilic shell due to the disassociation of host-guest supramolecule, but also it could be released upon the shrinkage of the hydrophobic core including Azobenzene-based crosslinker. In the conclusion, we were able to design a carrier in the nanoscale with sustaineable drug release with light irradiation as an external and non-contact stimulus
  9. Keywords:
  10. Photosensitive Material ; Beta-Cyclodextrin ; Host-Guest Complex ; Azobenzene Compounds ; Biocompatible Nanogel ; Drug Release ; Controlled Release

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