A Study in Genome Editing with Clustered Regularly Interspaced Short Palindromic Repeats, M.Sc. Thesis Sharif University of Technology ; Sharifi Tabar, Mohsen (Supervisor) ; Rabiee, Hamid Reza (Co-Supervisor) ; Rohban, Mohammad Hossein (Co-Supervisor)
Abstract
Clustered Regularly Interspaced Short Palindromic Repeats, or in short, CRISPR is a relatively new technology that enables geneticists and medical researchers to edit parts of the genome by removing, adding, or altering parts of the DNA. Initially found in the genomes of prokaryotic organisms such as bacteria and archaea, this technology can cure many illnesses such as blindness and cancer. A significant issue for a practical application of CRISPR systems is accurately predicting the single guide RNA (sgRNA) on-target efficacy and off-target sensitivity. While some methods classify these designs, most algorithms are on separate data with different genes and cells. The lack of...
Cataloging briefA Study in Genome Editing with Clustered Regularly Interspaced Short Palindromic Repeats, M.Sc. Thesis Sharif University of Technology ; Sharifi Tabar, Mohsen (Supervisor) ; Rabiee, Hamid Reza (Co-Supervisor) ; Rohban, Mohammad Hossein (Co-Supervisor)
Abstract
Clustered Regularly Interspaced Short Palindromic Repeats, or in short, CRISPR is a relatively new technology that enables geneticists and medical researchers to edit parts of the genome by removing, adding, or altering parts of the DNA. Initially found in the genomes of prokaryotic organisms such as bacteria and archaea, this technology can cure many illnesses such as blindness and cancer. A significant issue for a practical application of CRISPR systems is accurately predicting the single guide RNA (sgRNA) on-target efficacy and off-target sensitivity. While some methods classify these designs, most algorithms are on separate data with different genes and cells. The lack of...
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