Detection of Phase Amplitude Coupling Within and Between Different Brain Areas for DBS ON/OFF in Parkinson Disease

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Haddadian, Farbod | 2021

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 55108 (19)
University: Sharif University of Technology
Department: Computer Engineering
Advisor(s): Rabiee, Hamid Reza; Manzuri Shalmani, Mohammad Taghi
Abstract:
Recent studies of brain activities indicate that Phase-Amplitude Coupling (PAC) between several regions of the brain, are meaningfully related to Parkinson’s Disease. In this research, we have studied PAC as a statistical measure in Parkinsonian patients’ brains while Deep Brain Stimulation treatment with different stimulation frequencies are being applied. In order to do so, we have investigated patients’ brain signals, and estimated PAC between regions of interest; afterwards, by using the estimated PAC values, we have found significant effects of the treatments on parkinsonian brains; furthermore, two treatments that are using 130 Hz and 340 Hz stimuli signals are compared. In this research, we have used patients’ brains data gathered in the University of Dusseldorf, and benefited from assessments of neuroscience experts
Keywords:
Phase-Amplitude Coupling (PAC) ; Parkinson Disease ; Deep Brain Stimulation (DBS) ; Brain Waves