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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 55539 (05)
- University: Sharif University of Technology
- Department: Electrical Engineering
- Advisor(s): Fardmanesh, Mehdi; Annabestani, Mohsen
- Abstract:
- Microfluidic technology is a field of science that deals with the design, implementation, optimization, and testing of fluid systems in small dimensions. This technology has made significant progress in various fields in the last decade, especially in medical engineering. As an interdisciplinary scientific field, this growing technology has many applications in medicine, pharmaceuticals, chemistry, and electronic industries. One of the primary applications of microfluidic devices is the development of "lab-on-a-chip" systems as point-of-care diagnostic tools, such as rapid diagnosis during surgery. A microfluidic system includes various functional modules: sample preparation and fluid transfer, fluid separation, and detection and analysis. In the meantime, the detection module is one of the main goals of related research around microfluidic technology. There are different methods to detect and measure the fluid and particles in the fluid, including microorganisms, and one of them is the flow cytometer. In the meantime, making a low-cost and accessible chip allows rapid prototyping of microfluidic chips and helps the development of this field of technology. In this research, different methods of making microfluidic chips have been investigated, then a cheap method for the rapid production of microfluidic devices has been proposed. This method can fabricate microfluidic chips that can be modified, and at the same time, its fabrication does not require bonding the channel structure with the substrate. With the above technique, a repeatable method, similar chips can be manufactured for use in industries. Also, the manufactured chips have self-aligned electrodes. Then the suitable circuits for detecting and measuring the impedance changes of the microfluidic channel were checked, and an optimal circuit was built and tested. Finally, a complete microfluidic system including a fluid transfer module, microfluidic chip, measurement module, and analysis module has been implemented, and two sets of fluid impedance detection and polystyrene bead detection tests have been performed to check the quality of microfluidic chip manufacturing.
- Keywords:
- Flowcytometry ; Rapid Prototyping ; Bioparticles ; Point-Of-Care Detection ; Microfluidic System ; Microfluidic Chip
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