Loading...

Synthesis of magnetic bio-nanocomposites for drug release and adsorption applications

Rezghi Rami, M ; Sharif University of Technology | 2022

49 Viewed
  1. Type of Document: Article
  2. DOI: 10.1016/j.sajce.2022.08.003
  3. Publisher: Elsevier B.V , 2022
  4. Abstract:
  5. Aims: Synthesis of nanocarrier Fe3O4/silica-starch/PNVCL for drug delivery and Fe3O4/GO-starch for antibiotic removal applications Background: In the first part, the new magnetic nanocomposite including Fe3O4 nanoparticles coated with silica, anchored starch nanoparticles, and poly(N-vinylcaprolactam) and then, loaded by acetazolamide. In the second part, magnetic starch nanocomposites were synthesized and modified with graphene oxide. Methods: The drug loading, release and intrinsic cytotoxicity were measured. Also, the potential of Fe3O4/GO-starch as an adsorbent to remove cephalexin antibiotics from aqueous solutions was evaluated. Result: In the first part, the maximum drug adsorption was occurred at pH = 7 on the nanocarrier and the Langmuir model looks more suitable for describing the adsorption process at room temperature. The second study showed that the maximum adsorption of cephalexin at pH 4 for magnetic nanocomposites in good agreement with the Freundlich model and the adsorption kinetics followed the quasi-quadratic model. Conclusion: It seems that the prepared nanocarrier Fe3O4/silica-starch/PNVCL can be utilized as a promising candidate for drug delivery. Also, magnetic nanocomposites of Fe3O4/GO-starch can be used as suitable and inexpensive adsorbents in cephalexin removal. © 2022
  6. Keywords:
  7. Drug adsorption ; Graphene oxide ; Nanocomposite ; Silica ; Starch
  8. Source: South African Journal of Chemical Engineering ; Volume 42 , 2022 , Pages 115-126 ; 10269185 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/pii/S1026918522000634