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Synthesis of Magnetic Nanocatalysis Based on Polyvinyl Derivatives and the Investigation of their Catalytic Activity in Organic Reactions

Jarahiyan Sedeh, Atefeh | 2022

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  1. Type of Document: Ph.D. Dissertation
  2. Language: Farsi
  3. Document No: 55928 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Matloubi Moghaddam, Firouz; Pourjavadi, Ali
  7. Abstract:
  8. In recent years, the use of various catalysts has become a powerful tool in the synthesis of a wide range of biologically important molecules and or natural products toward the formation of carbon-carbon and carbon-heteroatom bonds. In the first section, the synthesis of magnetic catalyst based on acrylonitrile was reported and an attempt was made to use an efficient support and ligand to immobilize copper metals. Then, its structure was characterized by different techniques. The catalytic activity of the prepared catalyst was confirmed in the formation of indolyl diketones and the desired products were successfully synthesized with good to excellent yields. In addition, the catalyst could be easily recovered by an external magnet and reused for at least 9 cycles without losing its activity (shown below). In the next step, the synthesized support was used to immobilize palladium metals, and after confirming the structure, the role of the catalyst was investigated in the formation of diaryl ethers and benzonitriles. Optimum conditions were obtained for two reactions which indicated more efficient conditions than previously reported methods (shown below).In the second section, the synthesis of magnetic catalyst based on the acrylic acid and copper metal-organic framework was reported and its catalytic activity was confirmed in the formation of 3-methyl-2-phenylimidazo[1, 2-α] pyridines. In this research, a simple and efficient method was introduced for the synthesis of new derivatives from the key structures of imidazo[1, 2-α] pyridines. The important point is to use dimethylsulfoxide, which is an available and cheap material, as a reaction solvent and also a methylating agent (shown below)
  9. Keywords:
  10. Carbon-Heteroatom Bond Formation ; Carbon-Carbon Forming Reaction ; Carbon-Hydrogen Bond Activation ; Metal-Organic Framework ; Acrylonitrile-Based Catalyst ; Magnetic Catalyst

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