Cancer Prediction Using cfDNA Methylation Patterns With Deep Learning Approach, M.Sc. Thesis Sharif University of Technology ; Soleymani Baghshah, Mahdieh (Supervisor)
Abstract
Liquid biopsy includes information about the progress of the tumor, the effectiveness of the treatment and the possibility of tumor metastasis. This type of biopsy obtains this information by doing diagnosis and enumerating genetic variations in cells and cell-free DNA (cfDNA). Only a small fraction of cfDNA which might be free circulation tumor DNA (ctDNA) fragments, has mutations and is usually identified by epigenetic variations. On the other hand, the use of liquid biopsy has decreased, and tumors in the final stages are often untreatable due to the low accuracy in prediction of cancer. In this research, the aim is to predict cancer using cfDNA methylation patterns. We obtain these...
Cataloging briefCancer Prediction Using cfDNA Methylation Patterns With Deep Learning Approach, M.Sc. Thesis Sharif University of Technology ; Soleymani Baghshah, Mahdieh (Supervisor)
Abstract
Liquid biopsy includes information about the progress of the tumor, the effectiveness of the treatment and the possibility of tumor metastasis. This type of biopsy obtains this information by doing diagnosis and enumerating genetic variations in cells and cell-free DNA (cfDNA). Only a small fraction of cfDNA which might be free circulation tumor DNA (ctDNA) fragments, has mutations and is usually identified by epigenetic variations. On the other hand, the use of liquid biopsy has decreased, and tumors in the final stages are often untreatable due to the low accuracy in prediction of cancer. In this research, the aim is to predict cancer using cfDNA methylation patterns. We obtain these...
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