Simulation, Design, and Fabrication of a Droplet-Based Microfluidic Device to Study The Role of Tumor Microenvironment and Drug Effects on the Behavior of Multicellular Tumor Spheroids, Ph.D. Dissertation Sharif University of Technology ; Shamloo, Amir (Supervisor) ; Kazemzadeh Hannani, Siamak (Supervisor)
Abstract
Despite the extensive research conducted so far to treat cancer, this disease is still one of the main causes of death worldwide. The results of recent studies reveal the importance of the tumor microenvironment in the growth, proliferation, and invasion of the primary tumor. Most common models in cancer research, such as 2-dimensional in vitro models and xenografts, do not have sufficient ability to mimic the interaction of tumors with human stromal tissue. Therefore, the implementation of 3-dimensional in vitro models with the ability to replicate tumor microenvironments is essential. In this study, a microfluidic platform has been introduced to create parallel models of the tumor...
Cataloging briefSimulation, Design, and Fabrication of a Droplet-Based Microfluidic Device to Study The Role of Tumor Microenvironment and Drug Effects on the Behavior of Multicellular Tumor Spheroids, Ph.D. Dissertation Sharif University of Technology ; Shamloo, Amir (Supervisor) ; Kazemzadeh Hannani, Siamak (Supervisor)
Abstract
Despite the extensive research conducted so far to treat cancer, this disease is still one of the main causes of death worldwide. The results of recent studies reveal the importance of the tumor microenvironment in the growth, proliferation, and invasion of the primary tumor. Most common models in cancer research, such as 2-dimensional in vitro models and xenografts, do not have sufficient ability to mimic the interaction of tumors with human stromal tissue. Therefore, the implementation of 3-dimensional in vitro models with the ability to replicate tumor microenvironments is essential. In this study, a microfluidic platform has been introduced to create parallel models of the tumor...
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