Investigation of 3D Printed Microfluidic System for Continues Drug Synthesis, M.Sc. Thesis Sharif University of Technology ; Kazemeini, Mohammad (Supervisor) ; Hosseinpour, Vahid (Co-Supervisor)
Abstract
In recent years, batch systems were often used in the synthesis of pharmaceuticals. Nowadays, due to the possibility of more optimal conditions in flow systems, such as better mixing and optimal performance of heat transfer and mass transfer, process safety, reduction of retention time, and ease in increasing the scale of the process, the use of flow systems has been expanded. B-hydroxysulfone is a pharmaceutical intermediate in the production of bicalutamide, which is used in the treatment of prostate cancer and is used in many organic and biological processes. The reaction time in batch systems is about 17 to 20 hours, and in the flow system, the retention time has reached about 180-90...
Cataloging briefInvestigation of 3D Printed Microfluidic System for Continues Drug Synthesis, M.Sc. Thesis Sharif University of Technology ; Kazemeini, Mohammad (Supervisor) ; Hosseinpour, Vahid (Co-Supervisor)
Abstract
In recent years, batch systems were often used in the synthesis of pharmaceuticals. Nowadays, due to the possibility of more optimal conditions in flow systems, such as better mixing and optimal performance of heat transfer and mass transfer, process safety, reduction of retention time, and ease in increasing the scale of the process, the use of flow systems has been expanded. B-hydroxysulfone is a pharmaceutical intermediate in the production of bicalutamide, which is used in the treatment of prostate cancer and is used in many organic and biological processes. The reaction time in batch systems is about 17 to 20 hours, and in the flow system, the retention time has reached about 180-90...
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