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Charactrization of Oxidized Alginate- Gelatin Composite Hydrogel Reinforcement by Ti3C2Tx Mxene for Utilization in Biomedical Applications

Moazeni, Shima | 2022

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 56411 (07)
  4. University: Sharif University of Technology
  5. Department: Materials Science and Engineering
  6. Advisor(s): Nemati, Ali; Mashayekhan, Shohreh
  7. Abstract:
  8. Tissue engineering is a science that tries to create new tissues by using cells, growth factors and appropriate biological materials in order to repair damaged organs and replace parts lost due to various reasons. In this research, the effect of adding mxene sheets on the oxidized alginate-gelatin hydrogel scaffold was investigated. For this purpose, mxene nanosheets were first synthesized by Max phase chemical etching and its synthesis was confirmed by X-ray diffraction spectroscoy, field emission scanning electron microscope, X-ray energy diffraction spectroscopy, Fourier-transform infrared spectroscopy, UV-visible spectroscopy. Then, in order to prepare the scaffolds, different amounts of 0.1%, 0.3% and 0.5% of Ti3C2Mxene were added to the hydrogel composition, and the behavior of the fluid deformation under the effect of the applied stress field by the rheometric test, the study of the composition by Fourier transform infrared spectroscopy, the evaluation of the hydrogel conductivity were evaluated by resistance tester, mechanical properties were evaluated by pressure test, and also properties of swelling ratio and biodegradability (after 30 days in PBS solution) and cytotoxicity “by MTT assay” were evaluated. The results showed that the addition of mxene led to an increase in the water absorption and swelling behavior of the scaffolds and often increased the degradability. Also, it was seen that the Young's modulus increased from 40 kPa to 68 kPa and the conductivity of the scaffolds increased from 0.183 s/m to 0.512 s/m. It was observed that all The composite samples presented shear thinning behavior
  9. Keywords:
  10. Three Dimentional Printing ; Gelatin ; Titanium Carbide ; Conductive Hydrogels ; Composite Hydrogel ; Alginate Oxide ; Titanium Carbide Mxene Composite

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