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Numerical Study of Vascular Shear Stress Effects on Blood Clotting Processes

Asgharian, Navid | 2023

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 56453 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Firoozabadi, Bahar
  7. Abstract:
  8. Blood clotting and clot formation in damaged vessels are vital mechanisms of the body. Any disorder in performing this mechanism leads to various problems such as excessive bleeding or, on the contrary, causes vascular occlusion and diseases such as embolism. Due to the importance of this issue, extensive research has been done to understand this phenomenon and the factors affecting it. In this thesis, the effect of shear stress, coagulation factor concentration and wound location in coronary bifurcation on clot formation and growth and its interaction with velocity field is numerically investigated. Blood flow is modeled non-Newtonian with Carreau-Yasuda model. Various chemical species participate in the blood coagulation process, which ultimately results in coagulation by attaching platelets at the wound site and placing fibrin monomers on the platelets. To model the chemical reactions, 23 different chemical species are considered, which are modeled by convection-diffusion-reaction equations. Also, to obtain the flow field and pressure, momentum and continuity equations are solved simultaneously with 23 equations mentioned in COMSOL software. The results show that by reducing the speed at the inlet of the vessel and consequently reducing the shear stress, the thickness of the clot formed increases. Also, at the junction of the coronary artery branches, due to the presence of backflow, the thickness of the clot formed is much higher than other parts of the coronary arteries
  9. Keywords:
  10. Coronary Bifurcation ; Shear Stress ; Blood Coagulation Process ; Blood Clot ; Vascular Occlusion

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