Expremental Studying and Thermodynamic Modeling of Separation of Amino Acids by Ionic Liquids

Nazem, Hadi | 2011

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 42140 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Ghotbi, Cyrus; Taghikhani, Vahid; Vosoghi, Manochehr
  7. Abstract:
  8. In this work, partitioning of amino acids such as glutamic acid, phenyl anine and tryptophan in aqueous and ionic liquid phases at 298.15 K and atmospheric pressure was measured. [C4mim][Tf2N] is used due can produce two phase with water rapidly. Studying the effect of liquid solution pH on amino acids partitioning shows that increasing of pH results in decreasing of amino acid partitioning coefficient. This phenomenon pertains to electrostatic interactions between cation of amino acid and anion of ionic liquid which reduces when pH increases. Considering the effect of pH, liquid-liquid equilibrium data of amino acids was obtained in a pH that owning maximum partioning coefficient. Chemical structure of amino acid has an important effect on partitioning of amino acid between two phases. Experimental data reveals that glutamic acid mostly transfers to aqueous phase while tryptophan moves to ionic liquid phase. In modeling section, equilibrium behavior of water, amino acid and ionic liquid system is predicted by SAFT equation of state. Necessary parameters of water and pure ionic liquid for equation of state were measured and amino acid parameters were obtained from literature. Binary interaction of components were optimized by equilibrium data. NRTL model uses to compare the ability of SAFT equation of state to predict the behavior of system. Result indicates that SAFT equation of state anticipates the liquid-liquid equilibrium of system better than NRTL model.
  9. Keywords:
  10. Amino Acid ; Liquid-Liquid Equilibrium ; Ionic Liquids ; Statistical Assosiating Fluids Theory (SAFT) ; NonRandom Two Liquid-NonRandom Factor (NRTL-NRF)Model

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