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Diffusion of Lipid and Protein Molecules in Cell Membranes  

, Ph.D. Dissertation Sharif University of Technology Khoshnood, Atefeh (Author) ; Jalali, Abbas (Supervisor)
Abstract
Lipid membranes are fundamental constituents of cell membranes and are now used in lap-on-a-chip technology. Membranes in living cells contain a significant fraction of proteins, which undergo lateral random movements due to thermal fluctuations and shear forces imposed by the solvent fluid. Prominent natural and biotechnological systems where membranes are highly sheared include the plasma membrane of endothelial cells, and membranes used in biosensors for high throughput screening of drug candidates, and in water purification devices. In these systems membrane is in direct contact with the mainstream suspension flow, which is driven by pressure gradients. The efficiency and function of... 

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Diffusion of Lipid and Protein Molecules in Cell Membranes  

, Ph.D. Dissertation Sharif University of Technology Khoshnood, Atefeh (Author) ; Jalali, Abbas (Supervisor)
Abstract
Lipid membranes are fundamental constituents of cell membranes and are now used in lap-on-a-chip technology. Membranes in living cells contain a significant fraction of proteins, which undergo lateral random movements due to thermal fluctuations and shear forces imposed by the solvent fluid. Prominent natural and biotechnological systems where membranes are highly sheared include the plasma membrane of endothelial cells, and membranes used in biosensors for high throughput screening of drug candidates, and in water purification devices. In these systems membrane is in direct contact with the mainstream suspension flow, which is driven by pressure gradients. The efficiency and function of... 

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  • Contents (7)
  • List of Figures (9)
  • 1 Introduction (15)
  • 2 Continuum Model of Lipid Membranes (20)
    • 2.1 Introduction (20)
    • 2.2 Stretching and Compression (21)
    • 2.3 Shearing (22)
    • 2.4 Bending (22)
      • 2.4.1 Curvatures of a Surface (22)
      • 2.4.2 Monge Description (24)
  • 3 Molecular Dynamics Method for Coarse Grained Model of Lipid Membranes (26)
    • 3.1 Introduction (26)
    • 3.2 Lipid and Protein Models (27)
    • 3.3 Simulation Setup (29)
  • 4 Dynamical Properties of Lipid Membranes (32)
    • 4.1 Introduction (32)
    • 4.2 Clustering of Protein Inclusions in Lipid Bilayers (33)
    • 4.3 Friction Coefficient (35)
      • 4.3.1 Lipid Bilayer without Proteins (40)
      • 4.3.2 Lipid Bilayer with Protein Inclusions (43)
    • 4.4 Tilt Angle (46)
    • 4.5 Diffusion in Membranes (47)
      • 4.5.1 Diffusion coefficients and exponent (50)
      • 4.5.2 Diffusion of Lennard-Jones fluid (51)
      • 4.5.3 Diffusion of lipids (52)
      • 4.5.4 Diffusion of proteins (55)
    • 4.6 Conclusion (62)
  • 5 Stability of Suspension flows (64)
    • 5.1 Introduction (64)
    • 5.2 Governing diffusion and momentum equations (66)
      • 5.2.1 Steady-state solutions (68)
      • 5.2.2 Perturbed equations and eigenvalue problem (71)
    • 5.3 Long-lived and unstable modes (75)
    • 5.4 Conclusions (80)
  • 6 Membrane in Shear Flow: Continuum Approach (81)
    • 6.1 Introduction (81)
    • 6.2 Governing Momentum and diffusion equations (83)
    • 6.3 Perturbed equations and eigenvalue problem (87)
    • 6.4 Results (91)
    • 6.5 Conclusions (94)
  • References (96)
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