Modeling Flow and Fat Particle Deposition in Coronary Arteries

Biglarian, Mohit | 2013

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 44268 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Firoozabadi, Bahar; Saeedi, Mohammad Saeed
  7. Abstract:
  8. In this thesis, flow hemodynamic parameters and white blood cell deposition on the 3- D of coronary artries of heart coronary walls are studied. At first, numerical simulation of blood flow and without the presence of white cells is performed. Then, using the Lagrangian approach, white blood cells as solid particles are tracked considering forces such as drag force, weight, buoyancy, Saffman lift force, virtual mass in one way coupling method. this particle representive of white blood cells and play significant role in low density lipoprotein (LDL) deposition.The results show that a low shear region occurs on myocardial wall. maximum flow velocity near the bifurcation towards epicardial wall and inner wall that lead to reduce wall shear rate on myocardial wall. artery dynamic movement lead to change flowrate ratio between branches. although this movement does not cause much change in the size of the shear stress wall, but due to changes in particles inertia increases the probability of particle collisions to the walls. Low shear rate on myocardial wall and high gradient wall shear rate near the bifurcation cause particle deposition on bifurcation and myocardial wall. In this places due to vessel wall cells, endothelial, damage increase monocyte influence that wall causing the formation and development of atherosclerosis disease
  9. Keywords:
  10. Computational Fluid Dynamics (CFD) ; Coronary Arteries ; Particles Tracking ; Atherosclerosis ; Dynamic Mesh

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