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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 44854 (06)
- University: Sharif University of Technology
- Department: Chemical and Petroleum Engineering
- Advisor(s): Goodarznia, Iraj
- Abstract:
- In this study the main goal is to prepare a membrane to perform delayed drug release and absorbtion in the human body. To do so the supercritical method was used. A well-known biodegradable polymer was used. These kinds of polymers are used in drug delivery, wound dressing or scaffolding for cell culture. A membrane produced out of these kin of polymers is expected to have a good accordance with the goals.Ploy Vinyl alcohol, having very good bio degradable characteristics was used as the main polymer and Poly Ethylene Glycol (PEG) was used as an additive to make changes in the membrane structure. Also Dimethyl Sulfoxide, a polar solvent having the capability of solving both polymers is used. Carbon dioxide was used as the anti-solvent to create a super saturation in the solution.To investigate the operational parameters on the structure of the produced membrane, pore sizes and their size distribution is considered as a parameter for membrane structure. The investigated parameters are: Temperature, Pressure and Poly Ethylene Glycol concentration in the primary solution. Increasing the temperature and pressure increased the pore sizes 2.51 and 1.75 micrometers respectively. Also increasing the concentration of PEG increased the pore sizes to 11.31 micrometers and then decreased them to 4.4 micrometers. The dense layer on the surface of the membrane which was reported in the previous studies was removed due to the change in the preparing procedure.To decrease the number of experimental runs, Taguchi model with an L16 array was used
- Keywords:
- Membranes ; Polymers ; Delayed Release ; Superfluid System ; Drug Release
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