Mesoporous silica nanoparticles (MCM-41) coated PEGylated chitosan as a pH-Responsive nanocarrier for triggered release of erythromycin [electronic resource]

Pourjavadi, A. (Ali) ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1080/00914037.2013.862534
  3. Abstract:
  4. A pH-responsive drug delivery system based on core shell structure of mesoporous silica nanoparticle (MSN) and chitosan-PEG copolymer was prepared and characterized by Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), scanning electron microscope (SEM), and high-resolution transmission microscope (HR-TEM) techniques. In order to improve compatibility MSN and drug, mesoporous nanosilica was modified by 3-aminopropyl triethoxysilane. The release of erythromycin (a macrolide antibiotic) as a model drug was investigated in two pHs, 7.4 and 5.5
  5. Keywords:
  6. Mesoporous silica ; Nanocarrier ; PEGylated chitosan ; PH responsive
  7. Source: International Journal of Polymeric Materials and Polymeric Biomaterials ; 2014, Volume 63, Issue 13, Pages 692-697
  8. URL: http://www.tandfonline.com/doi/full/10.1080/00914037.2013.862534#tabModule