Construction of Pt nanoparticle-decorated graphene nanosheets and carbon nanospheres nanocomposite-modified electrodes: Application to ultrasensitive electrochemical determination of cefepime

Shahrokhian, S ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1039/c3ra44309d
  3. Abstract:
  4. A novel ultrasensitive modified electrode was fabricated with a graphene nanosheets and carbon nanospheres (GNS-CNS)-based nanocomposite film as a powerful platform. Pt nanoparticles (PtNPs) were simply electrodeposited onto the GNS-CNS-coated glassy carbon electrode creating a PtNPs/GNS-CNS hybrid nanocomposite modified electrode. Scanning electron microscopy, energy dispersive X-ray spectroscopy and linear sweep voltammetry (LSV) techniques were used for the characterization of the prepared modified electrode. The results of investigation of electrochemical response characteristics of cefepime (CP) revealed a considerable improvement in the oxidation peak current of CP on PtNPs/GNS-CNS/GCE compared to GNS-CNS/GCE or PtNPs/GCE. The observation of a synergistic effect between GNS-CNS and PtNPs is related to the electroactivity enhancement of PtNPs in the constructed nanostructured composite due to high electron-transfer ability of GNS-CNS. Under optimal conditions, the modified electrode showed high sensitivity (b(CP) = dIp,a(CP)/d[CP] = 1747.2 nA nM-1), a low detection limit (LOD (CP) = 1.2 nM, S/N = 3) and a wide linear dynamic range (8 nM to 6 μM) for the voltammetric determination of CP. The prepared electrode was successfully applied for the accurate determination of trace amounts of CP in pharmaceutical and clinical samples
  5. Keywords:
  6. Electrochemical determination ; Electrochemical response ; Energy dispersive X ray spectroscopy ; Glassy carbon electrodes ; Linear dynamic ranges ; Linear sweep voltammetry ; Nanostructured composites ; Voltammetric determination ; Chemical detection ; Glass membrane electrodes ; Graphene ; Nanocomposites ; Nanoparticles ; Nanosheets ; Platinum ; Scanning electron microscopy ; X ray spectroscopy ; Nanospheres
  7. Source: RSC Advances ; Volume 4, Issue 15 , 2014 , Pages 7786-7794 ; ISSN: 20462069
  8. URL: http://pubs.rsc.org/en/Content/ArticleLanding/2014/RA/c3ra44309d#!divAbstract