Fabrication of an electrochemical sensor based on the electrodeposition of Pt nanoparticles on multiwalled carbon nanotubes film for voltammetric determination of ceftriaxone in the presence of lidocaine, assisted by factorial-based response-surface methodology

Shahrokhian, S ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1007/s10008-013-2243-8
  3. Abstract:
  4. A glassy carbon electrode (GCE) is modified with platinum nanoparticle (PtNPs) decorated multiwalled carbon nanotube (MWCNT). The modified electrode is applied for the determination of ceftriaxone (CFX) in the presence of lidocaine. Different methods were used to characterize the surface morphology of the modified electrode. The electrochemical behavior of CFX was investigated at GCE, MWCNT/GCE and PtNPs/MWCNT/GCE. A factorial-based response-surface methodology was used to find out the optimum conditions with minimum number of experiments. Under the optimized conditions, oxidation peak currents increased linearly with CFX concentration in the range of 0.01-10.00 μM with a detection limit of 9.01 nM. The results prove that the modified electrode is also suitable for the determination of CFX in pharmaceutical and clinical preparations
  5. Keywords:
  6. Ceftriaxone ; Cyclic voltammetry ; Experimental design ; Multiwalled carbon nanotube ; Platinium nanoparticle ; Ceftriaxone ; Electrochemical behaviors ; Glassy carbon electrodes ; Modified electrodes ; Optimized conditions ; Platinum nano-particles ; Response-surface methodology ; Voltammetric determination ; Cyclic voltammetry ; Design of experiments ; Multiwalled carbon nanotubes (MWCN) ; Nanoparticles ; Platinum ; Glass membrane electrodes
  7. Source: Journal of Solid State Electrochemistry ; Vol. 18, issue. 1 , 2014 , p. 77-88
  8. URL: http://link.springer.com/article/10.1007%2Fs10008-013-2243-8